Correlation between Oral Thiamine as an Opioid Adjuvant and Cathecol-O-Methyltransferase Enzyme Levels in Cervical Cancer Patients

BACKGROUND: The high prevalence of cancer pain shows that a lot the patients are undertreatment. Vitamin B is one additional alternative substances studied in management. Thiamine believed to modulate mechanisms lowering Cathecol-O-Methyltransferase (COMT) enzyme level. AIM: aim study was assess correlation between Oral as an Opioid Adjuvant and COMT Enzyme Levels Cervical Cancer Patients METHODS: This research quasi-experimental with pre-test post-test control group design. this were 32 cervical who experienced pain, divided into two groups (treatment groups). treatment received morphine plus thiamine 500 mg/8 h/oral, alone. Measurement evaluation scores carried out after 72 h administration blood collection again 4 last check levels COMT. Then, data analysis being evaluated. RESULTS: From studied, there differences changes numeric rating scale (NRS) group. CONCLUSIONS: can reduce clinically NRS patients. If it confirmed by other findings, might be considered for its use pain.